Bills running back LeSean McCoy helped deal the Rams a 30-19 loss which dropped them from first place in the division.

SAN FRANCISCO 49ERS

Last time out: Cardinals 33, 49ers 21

Record: 1-4 overall, 1-2 in division

Snapshot: The 49ers grabbed an early 7-0 lead but the Cardinals scored 31 of the next 38 points to take control. San Francisco knew the Cardinals would try to run the ball with a backup quarterback under center, but still gave up 157 rushing yards and two scores to David Johnson.

Notable: San Francisco quarterback Blaine Gabbert was 18-of-31 for 162 yards with a touchdown and two interceptions. He was sacked seven times. The 49ers had a forgettable start to the second half. Kick returner Chris Davis lost a fumble on the kickoff, and then a running into the kicker penalty on a field goal try gave the Cardinals a first down, which they turned into seven points.

Quotable:  "We want Kap!" – chants from the Levi's Stadium crowd in the second half, as a segment of fans are hoping to see Colin Kaepernick at quarterback this week.

Injury update:Davis was placed on injured reserve with a knee injury he suffered against the Cardinals.

Next up: The 49ers travel to play the Bills in Week 6

SEATTLE SEAHAWKS

Last time out: The Seahawks were idle in Week 5

Record: 3-1 overall, 1-1 in division

Bye-week synopsis:The Seahawks started slowly this season, scoring 15 combined points in a tight win over the Dolphins and a loss to the Rams. They have looked better of late in double-digit wins over the 49ers and Jets to move into first place in the NFC West. Seattle has an elite defense and a star quarterback. That combination will always keep them competitive, but the running game and offensive line has to perform in order for the Seahawks to live up to the lofty standards of their recent seasons. Seattle will get a good test this week when they host the surprising Atlanta Falcons, who are tied for the second-best record in the NFC at 4-1 behind a powerful offense.

LOS ANGELES RAMS

Last time out: Bills 30, Rams 19

Record: 3-2 overall, 2-1 in division

Snapshot: Bills cornerback Nickell Robey-Coleman returned an interception 41 yards for the go-ahead touchdown late in the third quarter and Buffalo pulled away for the win. The Rams gave up 193 yards rushing, including 150 to LeSean McCoy.

Notable: The Rams got into Buffalo territory on seven of their first nine possessions but emerged with only 19 points. Los Angeles turned the ball over three times and didn't register a takeaway. The Rams opted for a field goal on a fourth-and-goal from the 4 with 6:34 remaining, trailing by a touchdown.

Quotable: "We let him break us. We let him run all over us. Not happy about that at all." - defensive tackle Aaron Donald, via therams.com, on McCoy's big game. The Rams were missing three starting defensive linemen.

Injury report:Cornerback Trumaine Johnson was carted off the field after suffering an ankle injury in the fourth quarter.* *

Next up: The Rams travel to face the Lions in Week 6