D.J. Humphries was upbeat. "Can't wait to get out there," the tackle said Wednesday, although technically he had just been out there for practice. The Cardinals didn't go hard just two days after a game -- Bruce Arians called it a walkthrough, although the guys had helmets, unlike what I would consider a normal walkthrough -- and Humphries needs to be in the mix in a harsher environment. So too does guard Mike Iupati (although Iupati has been practicing limited the last couple of weeks even though he hasn't been playing.)

If Humphries and Iupati can play, however, does that get the Cardinals their original, anticipated offensive line on the field. From left to right, it was supposed to be Humphries, Iupati, Shipley, Boehm, Veldheer. That's what it was in the opener for a little bit, until Humphries had his leg rolled up on and suffered his knee sprain. Iupati was never 100 percent, with the triceps injury lingering since training camp. (Alex Boone, who hurt his pectoral muscle, is a guy Arians said will be reevaluated Thursday, and frankly, if there is a guy who would try and play through something, Boone is that guy -- especially against the 49ers, his former team.)

The problems with the offensive line aren't a secret or even very hard to see. The right side, with Boehm and Veldheer, is struggling, and that has nothing to do with injuries. I'll admit, I am surprised at the Veldheer issues. Out of whatever concerns you might have had about the line as constructed, Veldheer would've been last on the list, regardless of a move to the right side. If he and Boehm don't significantly up their level of play, the rest of the line won't matter. But it would be something to see the Cardinals' original lineup on the field for a whole game and see what it might mean.